Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Rosiglitazone
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone may inhibit OATP1B1 in vitro, which could theoretically increase valsartan exposure. No clinically significant pharmacokinetic effect is established. Thiazolidinediones cause fluid retention and edema, which may partly offset antihypertensive therapy and add to amlodipine-related edema.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Rosiglitazone belongs to Endocrine.
Why it happens
Theoretical OATP1B1 inhibition affecting valsartan uptake; additive fluid retention from rosiglitazone and amlodipine.
What to do
Monitor blood pressure and for edema or heart failure symptoms. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Rosiglitazone?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rosiglitazone may inhibit OATP1B1 in vitro, which could theoretically increase valsartan exposure. No clinically significant pharmacokinetic effect is established. Thiazolidinediones cause fluid retention and edema, which may partly offset antihypertensive therapy and add to amlodipine-related edema.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or heart failure symptoms. No routine dose adjustment is needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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