Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Simvastatin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine increases simvastatin exposure, which raises the risk of myopathy and rhabdomyolysis. Labeling restricts the simvastatin daily dose when the two are used together.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Amlodipine weakly inhibits CYP3A4 metabolism of simvastatin, raising simvastatin and its active acid exposure.
What to do
Limit simvastatin to 20 mg daily with amlodipine, or switch to a statin less dependent on CYP3A4 such as rosuvastatin or pravastatin. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Simvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Simvastatin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine increases simvastatin exposure, which raises the risk of myopathy and rhabdomyolysis. Labeling restricts the simvastatin daily dose when the two are used together.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit simvastatin to 20 mg daily with amlodipine, or switch to a statin less dependent on CYP3A4 such as rosuvastatin or pravastatin. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
