Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Succinylcholine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can transiently raise serum potassium, while hydrochlorothiazide commonly lowers it. Electrolyte disturbances and thiazide-related hypokalemia may alter neuromuscular blockade and increase arrhythmia risk during anesthesia. Anesthetic agents may also add to hypotension with the antihypertensive combination.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Opposing effects on serum potassium and altered neuromuscular response in electrolyte disturbance.
What to do
Check potassium before elective procedures and correct abnormalities. Monitor ECG, electrolytes and neuromuscular function perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Succinylcholine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can transiently raise serum potassium, while hydrochlorothiazide commonly lowers it. Electrolyte disturbances and thiazide-related hypokalemia may alter neuromuscular blockade and increase arrhythmia risk during anesthesia. Anesthetic agents may also add to hypotension with the antihypertensive combination.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium before elective procedures and correct abnormalities. Monitor ECG, electrolytes and neuromuscular function perioperatively.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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