Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Tipranavir
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir inhibits CYP3A4 and may raise amlodipine concentrations, increasing hypotension and edema. Tipranavir also has mixed inhibition and induction effects on CYP3A4 so the net effect varies.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir-boosted tipranavir reduces amlodipine metabolism.
What to do
Monitor blood pressure and edema, and use a lower amlodipine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Tipranavir?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted tipranavir inhibits CYP3A4 and may raise amlodipine concentrations, increasing hypotension and edema. Tipranavir also has mixed inhibition and induction effects on CYP3A4 so the net effect varies.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and use a lower amlodipine dose if adverse effects appear.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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