Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Tizanidine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is a central alpha-2 agonist that lowers blood pressure and may cause hypotension, dizziness and bradycardia. With a triple antihypertensive combination the effects are additive.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive blood pressure lowering through central alpha-2 agonism and the antihypertensive agents.
What to do
Monitor blood pressure and counsel on orthostatic symptoms. Start tizanidine at a low dose and reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Tizanidine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is a central alpha-2 agonist that lowers blood pressure and may cause hypotension, dizziness and bradycardia. With a triple antihypertensive combination the effects are additive.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel on orthostatic symptoms. Start tizanidine at a low dose and reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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