Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Trientine
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Trientine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may alter trientine handling, but a clinically relevant reduction in trientine effect is not well established. Trientine can also lower iron and other mineral levels, which is unrelated to this combination.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Trientine belongs to Miscellaneous.
Why it happens
Possible altered renal clearance; mechanism not firmly established.
What to do
Monitor urinary copper excretion and clinical response in Wilson disease when starting or stopping the thiazide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Trientine
- Calcium + Trientine Moderate
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Trientine?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Trientine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may alter trientine handling, but a clinically relevant reduction in trientine effect is not well established. Trientine can also lower iron and other mineral levels, which is unrelated to this combination.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Trientine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary copper excretion and clinical response in Wilson disease when starting or stopping the thiazide.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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