Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Voriconazole
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, the main enzyme that clears amlodipine, so amlodipine exposure can rise. This may cause excessive vasodilation with hypotension, dizziness and peripheral edema.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of amlodipine, raising its plasma concentrations.
What to do
Monitor blood pressure and edema when voriconazole is started or stopped. Reduce the amlodipine dose if hypotension or marked edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Voriconazole?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, the main enzyme that clears amlodipine, so amlodipine exposure can rise. This may cause excessive vasodilation with hypotension, dizziness and peripheral edema.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when voriconazole is started or stopped. Reduce the amlodipine dose if hypotension or marked edema develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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