Drug interactions
Amlodipine-olmesartan + Avanafil
Severity: Moderate
Amlodipine-olmesartan and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor with vasodilating properties that can lower blood pressure. With amlodipine and olmesartan, additive hypotension may occur, causing dizziness or syncope.
What this interaction means in plain words
Amlodipine-olmesartan and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation from nitric oxide pathway potentiation by PDE5 inhibition and the antihypertensive actions of amlodipine and olmesartan.
What to do
Use the lowest avanafil dose initially and advise patients to rise slowly. Monitor blood pressure and counsel on symptoms of hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Avanafil?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor with vasodilating properties that can lower blood pressure. With amlodipine and olmesartan, additive hypotension may occur, causing dizziness or syncope.
How serious is the interaction between Amlodipine-olmesartan and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest avanafil dose initially and advise patients to rise slowly. Monitor blood pressure and counsel on symptoms of hypotension.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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