Drug interactions
Amlodipine-olmesartan + Enzalutamide
Severity: Moderate
Amlodipine-olmesartan and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a moderate to strong CYP3A4 inducer and can reduce amlodipine concentrations. This may result in reduced antihypertensive effect.
What this interaction means in plain words
Amlodipine-olmesartan and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 increases the metabolism of amlodipine.
What to do
Monitor blood pressure after starting or stopping enzalutamide and increase the amlodipine dose if needed. Consider an alternative antihypertensive if control remains inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Enzalutamide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a moderate to strong CYP3A4 inducer and can reduce amlodipine concentrations. This may result in reduced antihypertensive effect.
How serious is the interaction between Amlodipine-olmesartan and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping enzalutamide and increase the amlodipine dose if needed. Consider an alternative antihypertensive if control remains inadequate.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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