Drug interactions
Amlodipine-olmesartan + Posaconazole
Severity: Moderate
Amlodipine-olmesartan and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole strongly inhibits CYP3A4 and can increase amlodipine exposure, leading to hypotension, dizziness and peripheral edema. The effect is more pronounced in elderly patients.
What this interaction means in plain words
Amlodipine-olmesartan and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of amlodipine.
What to do
Monitor blood pressure and edema, and reduce the amlodipine dose if hypotension or edema develops. Reassess when posaconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Posaconazole?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole strongly inhibits CYP3A4 and can increase amlodipine exposure, leading to hypotension, dizziness and peripheral edema. The effect is more pronounced in elderly patients.
How serious is the interaction between Amlodipine-olmesartan and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the amlodipine dose if hypotension or edema develops. Reassess when posaconazole is stopped.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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