Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Atazanavir
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Atazanavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the risk of hypotension, dizziness and edema. Labeling for atazanavir suggests considering a lower amlodipine dose.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Atazanavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism.
What to do
Monitor blood pressure and edema, and consider reducing the amlodipine dose; use separate components if dose adjustment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Atazanavir?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the risk of hypotension, dizziness and edema. Labeling for atazanavir suggests considering a lower amlodipine dose.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Atazanavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and consider reducing the amlodipine dose; use separate components if dose adjustment is needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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