Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Chloramphenicol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 and may raise amlodipine concentrations. This can lead to excessive hypotension, dizziness and peripheral edema, although the effect is generally modest and clinical data are limited.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 metabolism of amlodipine by chloramphenicol.
What to do
Monitor blood pressure and for edema or dizziness during chloramphenicol therapy. Reduce the amlodipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Chloramphenicol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits CYP3A4 and may raise amlodipine concentrations. This can lead to excessive hypotension, dizziness and peripheral edema, although the effect is generally modest and clinical data are limited.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or dizziness during chloramphenicol therapy. Reduce the amlodipine dose if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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