Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Cholestyramine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Cholestyramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces how much is absorbed. This can weaken the diuretic and antihypertensive effect of the triple combination tablet. Olmesartan absorption may also be reduced by bile acid sequestrants.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Cholestyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Cholestyramine belongs to Cardiovascular.
Why it happens
Anion-exchange resin adsorbs hydrochlorothiazide (and potentially olmesartan) in the gastrointestinal tract, reducing absorption.
What to do
Give the combination tablet at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure and adjust therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Cholestyramine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Cholestyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces how much is absorbed. This can weaken the diuretic and antihypertensive effect of the triple combination tablet. Olmesartan absorption may also be reduced by bile acid sequestrants.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Cholestyramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the combination tablet at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure and adjust therapy if control is lost.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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