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Drug interactions

Amlodipine-olmesartan-hydrochlorothiazide + Cisatracurium

Severity: Minor

Amlodipine-olmesartan-hydrochlorothiazide and Cisatracurium: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Calcium channel blockers may enhance neuromuscular blockade from cisatracurium, prolonging recovery. Clinical effects are generally modest.

What this interaction means in plain words

Amlodipine-olmesartan-hydrochlorothiazide and Cisatracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Cisatracurium belongs to Musculoskeletal.

Evidence level: Low

Why it happens

Calcium channel blockade reduces presynaptic acetylcholine release, adding to neuromuscular blockade.

What to do

Monitor neuromuscular function with a nerve stimulator during anesthesia and titrate the blocker dose accordingly.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Amlodipine-olmesartan-hydrochlorothiazide with Cisatracurium?

MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Cisatracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may enhance neuromuscular blockade from cisatracurium, prolonging recovery. Clinical effects are generally modest.

How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Cisatracurium?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator during anesthesia and titrate the blocker dose accordingly.

What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?

MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.

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