Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Diazoxide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and diazoxide both raise blood glucose and can cause hyperuricemia. Together they may produce additive hyperglycemia and may also augment hypotension.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Diazoxide belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects: diazoxide suppresses insulin release and thiazides impair glucose tolerance, with additive antihypertensive effect.
What to do
Monitor blood glucose, blood pressure and serum uric acid, and adjust diabetic therapy or the diazoxide dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Diazoxide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and diazoxide both raise blood glucose and can cause hyperuricemia. Together they may produce additive hyperglycemia and may also augment hypotension.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and serum uric acid, and adjust diabetic therapy or the diazoxide dose as required.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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