Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Felodipine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a dihydropyridine calcium channel blocker, so giving it with a combination product already containing amlodipine duplicates therapy. This increases the risk of hypotension, dizziness and peripheral oedema without meaningful added benefit.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Felodipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blockade of L-type calcium channels in vascular smooth muscle by two dihydropyridines.
What to do
Avoid combining two dihydropyridine calcium channel blockers; stop one of them. If both are continued, monitor blood pressure and oedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Felodipine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine is a dihydropyridine calcium channel blocker, so giving it with a combination product already containing amlodipine duplicates therapy. This increases the risk of hypotension, dizziness and peripheral oedema without meaningful added benefit.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridine calcium channel blockers; stop one of them. If both are continued, monitor blood pressure and oedema.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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