Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Folic acid
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may modestly increase urinary loss of water-soluble vitamins such as folate. In patients with adequate diet and supplementation this is unlikely to cause clinically relevant deficiency.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Folic acid belongs to Miscellaneous.
Why it happens
Increased renal excretion of folate during diuretic-induced diuresis; the mechanism is not firmly established.
What to do
No routine action is needed; consider checking folate status in patients with poor intake, alcohol use or long-term high-dose diuretic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Folic acid?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may modestly increase urinary loss of water-soluble vitamins such as folate. In patients with adequate diet and supplementation this is unlikely to cause clinically relevant deficiency.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; consider checking folate status in patients with poor intake, alcohol use or long-term high-dose diuretic therapy.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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