Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Indomethacin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the antihypertensive effects of olmesartan and hydrochlorothiazide. Together with an ARB and diuretic it increases the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandins by indomethacin causes sodium retention and reduced glomerular perfusion, opposing the ARB and diuretic and impairing renal function.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer a safer analgesic where possible, or limit indomethacin to the shortest course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Indomethacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Indomethacin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the antihypertensive effects of olmesartan and hydrochlorothiazide. Together with an ARB and diuretic it increases the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer a safer analgesic where possible, or limit indomethacin to the shortest course.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
