Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Lemborexant
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may increase lemborexant exposure. This can increase next-day somnolence and impairment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces lemborexant metabolism.
What to do
Limit lemborexant to the lower maximum nightly dose recommended with weak CYP3A4 inhibitors and monitor for daytime sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Lemborexant?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may increase lemborexant exposure. This can increase next-day somnolence and impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower maximum nightly dose recommended with weak CYP3A4 inhibitors and monitor for daytime sedation.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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