Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Lenacapavir
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise amlodipine concentrations. This can cause hypotension and edema, and the effect may persist for months after the last subcutaneous dose.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing amlodipine clearance.
What to do
Monitor blood pressure and edema, and reduce the amlodipine dose if needed. Continue monitoring after lenacapavir is stopped because of its prolonged effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Lenacapavir?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise amlodipine concentrations. This can cause hypotension and edema, and the effect may persist for months after the last subcutaneous dose.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the amlodipine dose if needed. Continue monitoring after lenacapavir is stopped because of its prolonged effect.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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