Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Lesinurad
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak CYP3A inducer and may modestly lower amlodipine exposure, potentially reducing blood pressure control. The effect is likely small. Note that lesinurad has been discontinued in many markets.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Lesinurad belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4 by lesinurad increases amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping lesinurad and increase the amlodipine dose only if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Lesinurad?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is a weak CYP3A inducer and may modestly lower amlodipine exposure, potentially reducing blood pressure control. The effect is likely small. Note that lesinurad has been discontinued in many markets.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping lesinurad and increase the amlodipine dose only if control is lost.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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