Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Mesalamine
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine can cause renal impairment, and thiazide-induced volume depletion may add to renal risk. A direct pharmacokinetic interaction at tubular secretion is theoretical and minor.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Theoretical competition for renal tubular secretion, together with additive renal stress from volume depletion.
What to do
Monitor renal function periodically and maintain hydration during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Mesalamine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Mesalamine?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesalamine can cause renal impairment, and thiazide-induced volume depletion may add to renal risk. A direct pharmacokinetic interaction at tubular secretion is theoretical and minor.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically and maintain hydration during combined therapy.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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