Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Methoxsalen
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to deliberately induce photosensitivity in PUVA therapy. Using them together may increase the risk of exaggerated phototoxic reactions such as severe sunburn and blistering.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive phototoxic effects from two photosensitizing drugs.
What to do
Counsel on strict photoprotection and watch for erythema after UVA exposure. The PUVA dose may need to be reduced or the thiazide substituted with another antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Methoxsalen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Methoxsalen?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to deliberately induce photosensitivity in PUVA therapy. Using them together may increase the risk of exaggerated phototoxic reactions such as severe sunburn and blistering.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on strict photoprotection and watch for erythema after UVA exposure. The PUVA dose may need to be reduced or the thiazide substituted with another antihypertensive.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
