Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Nadolol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol adds to the blood pressure lowering of the triple combination, which can cause hypotension and bradycardia. Beta-blockers can also mask hypoglycemia, and renal excretion of nadolol means that reduced renal function may increase its effects.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects from beta-blockade with calcium channel blockade, ARB and diuretic action.
What to do
Monitor blood pressure, heart rate and renal function when starting or adjusting either treatment. Reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Nadolol
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Nadolol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol adds to the blood pressure lowering of the triple combination, which can cause hypotension and bradycardia. Beta-blockers can also mask hypoglycemia, and renal excretion of nadolol means that reduced renal function may increase its effects.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and renal function when starting or adjusting either treatment. Reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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