Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Phentolamine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is a non-selective alpha-blocker that lowers blood pressure and can cause marked hypotension and reflex tachycardia. Combined with the three antihypertensive components, additive hypotension is likely.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilatory and blood pressure lowering effects from alpha-adrenergic blockade together with calcium channel blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate closely, particularly after parenteral phentolamine doses. Reduce doses of antihypertensives if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Phentolamine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is a non-selective alpha-blocker that lowers blood pressure and can cause marked hypotension and reflex tachycardia. Combined with the three antihypertensive components, additive hypotension is likely.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely, particularly after parenteral phentolamine doses. Reduce doses of antihypertensives if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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