Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Probenecid
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and probenecid compete for renal tubular organic anion secretion. Probenecid may reduce the diuretic effect of thiazides, and thiazides can raise uric acid, opposing probenecid's uricosuric action.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for organic anion transporter-mediated renal tubular secretion, and thiazide-induced hyperuricemia counteracting uricosuria.
What to do
Monitor blood pressure response and serum uric acid; adjust the probenecid dose if gout control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Probenecid?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and probenecid compete for renal tubular organic anion secretion. Probenecid may reduce the diuretic effect of thiazides, and thiazides can raise uric acid, opposing probenecid's uricosuric action.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure response and serum uric acid; adjust the probenecid dose if gout control worsens.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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