Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Quinidine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is cleared partly by renal tubular cationic secretion and may modestly raise hydrochlorothiazide exposure. A more relevant concern is that thiazide-induced hypokalemia or hypomagnesemia increases the risk of quinidine-related QT prolongation and torsades de pointes.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Possible competition for renal tubular cation secretion, plus diuretic-induced electrolyte depletion that potentiates quinidine proarrhythmia.
What to do
Monitor serum potassium and magnesium and correct deficits promptly. Obtain an ECG if QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Quinidine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is cleared partly by renal tubular cationic secretion and may modestly raise hydrochlorothiazide exposure. A more relevant concern is that thiazide-induced hypokalemia or hypomagnesemia increases the risk of quinidine-related QT prolongation and torsades de pointes.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits promptly. Obtain an ECG if QT-prolonging risk factors are present.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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