Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Secobarbital
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower amlodipine concentrations and reduce its blood pressure effect. Barbiturates also add to hypotension and sedation in some patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturates induce hepatic CYP3A4, increasing amlodipine metabolism.
What to do
Monitor blood pressure when starting or stopping secobarbital and increase the amlodipine dose if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Secobarbital?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower amlodipine concentrations and reduce its blood pressure effect. Barbiturates also add to hypotension and sedation in some patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping secobarbital and increase the amlodipine dose if control is lost.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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