Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Sitagliptin
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may raise blood glucose and modestly reduce the glucose-lowering effect of sitagliptin. The clinical impact is usually small.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Sitagliptin belongs to Endocrine.
Why it happens
Thiazides cause pharmacodynamic antagonism through reduced insulin secretion and increased insulin resistance.
What to do
Monitor glucose control periodically and adjust antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Sitagliptin?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may raise blood glucose and modestly reduce the glucose-lowering effect of sitagliptin. The clinical impact is usually small.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control periodically and adjust antidiabetic therapy if control deteriorates.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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