Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Tolbutamide
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and may reduce the effectiveness of tolbutamide. The effect is usually small at low thiazide doses.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Thiazides cause pharmacodynamic antagonism by impairing insulin secretion and increasing insulin resistance.
What to do
Monitor blood glucose when the thiazide is started or changed and adjust the sulfonylurea dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Tolbutamide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and may reduce the effectiveness of tolbutamide. The effect is usually small at low thiazide doses.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the thiazide is started or changed and adjust the sulfonylurea dose if needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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