Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Vecuronium
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers such as amlodipine may enhance and prolong neuromuscular blockade from vecuronium. This could delay recovery after surgery.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Vecuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may reduce presynaptic acetylcholine release, adding to the postsynaptic blockade by vecuronium.
What to do
Monitor neuromuscular function with a train-of-four monitor and reduce vecuronium doses if blockade is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Vecuronium
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Vecuronium?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers such as amlodipine may enhance and prolong neuromuscular blockade from vecuronium. This could delay recovery after surgery.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a train-of-four monitor and reduce vecuronium doses if blockade is prolonged.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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