Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Verapamil
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil adds a second calcium channel blocker to amlodipine, increasing blood pressure lowering and the risk of edema, bradycardia and AV conduction slowing. Verapamil also inhibits CYP3A4 and may raise amlodipine exposure.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade plus verapamil inhibition of CYP3A4-mediated amlodipine metabolism.
What to do
Avoid routine duplication of calcium channel blockers; if combined, monitor blood pressure, heart rate and peripheral edema and reduce the dose of either drug if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Verapamil?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil adds a second calcium channel blocker to amlodipine, increasing blood pressure lowering and the risk of edema, bradycardia and AV conduction slowing. Verapamil also inhibits CYP3A4 and may raise amlodipine exposure.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of calcium channel blockers; if combined, monitor blood pressure, heart rate and peripheral edema and reduce the dose of either drug if needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
