Drug interactions
Amlodipine-perindopril + Aspirin rectal
Severity: Moderate
Amlodipine-perindopril and Aspirin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin at analgesic doses may weaken the blood pressure lowering effect of perindopril and impair renal function in vulnerable patients.
What this interaction means in plain words
Amlodipine-perindopril and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibition.
What to do
Monitor blood pressure, creatinine and potassium with regular analgesic-dose use and keep the patient hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Aspirin rectal?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin at analgesic doses may weaken the blood pressure lowering effect of perindopril and impair renal function in vulnerable patients.
How serious is the interaction between Amlodipine-perindopril and Aspirin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium with regular analgesic-dose use and keep the patient hydrated.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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