Drug interactions
Amlodipine-perindopril + Bretylium
Severity: Moderate
Amlodipine-perindopril and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium can cause hypotension through adrenergic neuron blockade. Combined with amlodipine and perindopril, hypotension may be intensified, which is important in an acutely ill patient.
What this interaction means in plain words
Amlodipine-perindopril and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects of adrenergic neuron blockade, vasodilation and ACE inhibition.
What to do
Monitor blood pressure closely during bretylium therapy and consider temporarily holding the oral antihypertensives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Bretylium?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium can cause hypotension through adrenergic neuron blockade. Combined with amlodipine and perindopril, hypotension may be intensified, which is important in an acutely ill patient.
How serious is the interaction between Amlodipine-perindopril and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during bretylium therapy and consider temporarily holding the oral antihypertensives.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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