Drug interactions
Amlodipine-perindopril + Butabarbital
Severity: Moderate
Amlodipine-perindopril and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital, a barbiturate, induces hepatic CYP3A4 and may lower amlodipine concentrations. Blood pressure control can weaken, particularly after the barbiturate has been taken for some time.
What this interaction means in plain words
Amlodipine-perindopril and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping butabarbital. Increase the amlodipine dose if needed, and reduce it again when the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Butabarbital?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital, a barbiturate, induces hepatic CYP3A4 and may lower amlodipine concentrations. Blood pressure control can weaken, particularly after the barbiturate has been taken for some time.
How serious is the interaction between Amlodipine-perindopril and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping butabarbital. Increase the amlodipine dose if needed, and reduce it again when the barbiturate is withdrawn.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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