Drug interactions
Amlodipine-perindopril + Butalbital
Severity: Minor
Amlodipine-perindopril and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing potential and may modestly reduce amlodipine exposure. With intermittent use the effect is usually small, but regular use could weaken blood pressure control.
What this interaction means in plain words
Amlodipine-perindopril and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 by butalbital increases amlodipine clearance.
What to do
Check blood pressure if butalbital is used frequently or long term. Adjust the amlodipine dose only if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Butalbital?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with enzyme-inducing potential and may modestly reduce amlodipine exposure. With intermittent use the effect is usually small, but regular use could weaken blood pressure control.
How serious is the interaction between Amlodipine-perindopril and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure if butalbital is used frequently or long term. Adjust the amlodipine dose only if control is lost.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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