Drug interactions
Amlodipine-perindopril + Calcium chloride
Severity: Moderate
Amlodipine-perindopril and Calcium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium can reverse the effects of calcium channel blockers and is used as an antidote in overdose. In patients on amlodipine, parenteral calcium may blunt its blood pressure lowering effect.
What this interaction means in plain words
Amlodipine-perindopril and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism, as higher extracellular calcium overcomes L-type calcium channel blockade.
What to do
Monitor blood pressure and heart rate when giving parenteral calcium to patients on amlodipine. Avoid using it unless there is a clear indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Calcium chloride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Calcium chloride?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium can reverse the effects of calcium channel blockers and is used as an antidote in overdose. In patients on amlodipine, parenteral calcium may blunt its blood pressure lowering effect.
How serious is the interaction between Amlodipine-perindopril and Calcium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when giving parenteral calcium to patients on amlodipine. Avoid using it unless there is a clear indication.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
