Drug interactions
Amlodipine-perindopril + Calcium citrate
Severity: Minor
Amlodipine-perindopril and Calcium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium supplements may theoretically antagonize calcium channel blockers, but with oral doses in normocalcemic patients the effect is negligible. A reduced antihypertensive effect would be expected only if hypercalcemia developed.
What this interaction means in plain words
Amlodipine-perindopril and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism of calcium channel blockade by raised calcium levels.
What to do
No routine action is needed. Check serum calcium if high doses are taken together with vitamin D.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Calcium citrate?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium supplements may theoretically antagonize calcium channel blockers, but with oral doses in normocalcemic patients the effect is negligible. A reduced antihypertensive effect would be expected only if hypercalcemia developed.
How serious is the interaction between Amlodipine-perindopril and Calcium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Check serum calcium if high doses are taken together with vitamin D.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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