Drug interactions
Amlodipine-perindopril + Carvedilol
Severity: Moderate
Amlodipine-perindopril and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol combined with amlodipine and perindopril produces additive blood-pressure lowering, and may cause dizziness or orthostatic hypotension. The combination is commonly used deliberately, for example in hypertension or heart failure, but doses need care.
What this interaction means in plain words
Amlodipine-perindopril and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive vasodilation and reduced cardiac output from beta- and alpha-blockade, calcium channel blockade and ACE inhibition.
What to do
Monitor blood pressure and heart rate, particularly during initiation and dose changes. Titrate gradually and warn patients about postural dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Amlodipine-perindopril with Carvedilol?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol combined with amlodipine and perindopril produces additive blood-pressure lowering, and may cause dizziness or orthostatic hypotension. The combination is commonly used deliberately, for example in hypertension or heart failure, but doses need care.
How serious is the interaction between Amlodipine-perindopril and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly during initiation and dose changes. Titrate gradually and warn patients about postural dizziness.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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