Drug interactions
Amlodipine-perindopril + Celiprolol
Severity: Moderate
Amlodipine-perindopril and Celiprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol is a beta-blocker with vasodilating activity, and combining it with amlodipine and perindopril adds to blood pressure lowering. This is often an intended combination, but it can cause excessive hypotension or bradycardia.
What this interaction means in plain words
Amlodipine-perindopril and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects through different pathways, with beta-blockade also reducing heart rate and contractility.
What to do
Monitor blood pressure and heart rate when starting or adjusting the combination. Reduce doses if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Celiprolol?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol is a beta-blocker with vasodilating activity, and combining it with amlodipine and perindopril adds to blood pressure lowering. This is often an intended combination, but it can cause excessive hypotension or bradycardia.
How serious is the interaction between Amlodipine-perindopril and Celiprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting the combination. Reduce doses if hypotension or bradycardia develops.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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