Drug interactions
Amlodipine-perindopril + Choline magnesium trisalicylate
Severity: Moderate
Amlodipine-perindopril and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Choline magnesium trisalicylate has weaker prostaglandin inhibition than most NSAIDs, but high doses may still reduce perindopril's antihypertensive effect and affect renal function in at-risk patients.
What this interaction means in plain words
Amlodipine-perindopril and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-mediated reduction in renal prostaglandins can lower renal perfusion and antagonize ACE inhibition.
What to do
Monitor blood pressure and serum creatinine and potassium during prolonged use, using the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Choline magnesium trisalicylate has weaker prostaglandin inhibition than most NSAIDs, but high doses may still reduce perindopril's antihypertensive effect and affect renal function in at-risk patients.
How serious is the interaction between Amlodipine-perindopril and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium during prolonged use, using the lowest effective dose.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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