Drug interactions
Amlodipine-perindopril + Dichlorphenamide
Severity: Minor
Amlodipine-perindopril and Dichlorphenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss and metabolic acidosis, whereas amlodipine does not meaningfully lower potassium. Perindopril tends to raise potassium and may partly offset this, so the net effect is unpredictable and no strong interaction is established.
What this interaction means in plain words
Amlodipine-perindopril and Dichlorphenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition increases renal potassium wasting, while ACE inhibition reduces aldosterone, giving opposing effects on potassium.
What to do
Check serum potassium and bicarbonate periodically during combined therapy and adjust potassium supplementation accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amlodipine-perindopril with Dichlorphenamide?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Dichlorphenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dichlorphenamide causes potassium loss and metabolic acidosis, whereas amlodipine does not meaningfully lower potassium. Perindopril tends to raise potassium and may partly offset this, so the net effect is unpredictable and no strong interaction is established.
How serious is the interaction between Amlodipine-perindopril and Dichlorphenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and bicarbonate periodically during combined therapy and adjust potassium supplementation accordingly.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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