Drug interactions
Amlodipine-perindopril + Diltiazem
Severity: Moderate
Amlodipine-perindopril and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem raises amlodipine exposure and adds to its blood pressure lowering effect, which may cause hypotension, edema or dizziness. Additive vasodilation and negative chronotropic effects may also be seen.
What this interaction means in plain words
Amlodipine-perindopril and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4, reducing amlodipine clearance, with additive calcium channel blockade.
What to do
Avoid routine combination of two calcium channel blockers unless specifically intended. If used, monitor blood pressure and heart rate and reduce the amlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Amlodipine-perindopril with Diltiazem?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem raises amlodipine exposure and adds to its blood pressure lowering effect, which may cause hypotension, edema or dizziness. Additive vasodilation and negative chronotropic effects may also be seen.
How serious is the interaction between Amlodipine-perindopril and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of two calcium channel blockers unless specifically intended. If used, monitor blood pressure and heart rate and reduce the amlodipine dose if needed.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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