Drug interactions
Amlodipine-perindopril + Doxazosin
Severity: Moderate
Amlodipine-perindopril and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining doxazosin with amlodipine and perindopril produces additive blood pressure lowering. Symptomatic hypotension, dizziness and syncope can occur, particularly with the first doxazosin dose or after dose increases.
What this interaction means in plain words
Amlodipine-perindopril and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive vasodilation via alpha-1 blockade, calcium channel blockade and renin-angiotensin inhibition.
What to do
Start doxazosin at a low dose at bedtime and titrate gradually while monitoring standing blood pressure; reduce other agents if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Doxazosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Amlodipine-perindopril with Doxazosin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining doxazosin with amlodipine and perindopril produces additive blood pressure lowering. Symptomatic hypotension, dizziness and syncope can occur, particularly with the first doxazosin dose or after dose increases.
How serious is the interaction between Amlodipine-perindopril and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start doxazosin at a low dose at bedtime and titrate gradually while monitoring standing blood pressure; reduce other agents if orthostatic symptoms occur.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
