Drug interactions
Amlodipine-perindopril + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Amlodipine-perindopril and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4, which can raise amlodipine concentrations and cause excess vasodilation, with hypotension and peripheral edema. The interaction is usually manageable with dose reduction and monitoring rather than being an absolute contraindication.
What this interaction means in plain words
Amlodipine-perindopril and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing amlodipine metabolism and increasing its exposure.
What to do
Monitor blood pressure and edema and consider reducing the amlodipine dose; use a lower-dose or alternative antihypertensive if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4, which can raise amlodipine concentrations and cause excess vasodilation, with hypotension and peripheral edema. The interaction is usually manageable with dose reduction and monitoring rather than being an absolute contraindication.
How serious is the interaction between Amlodipine-perindopril and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and consider reducing the amlodipine dose; use a lower-dose or alternative antihypertensive if hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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