Drug interactions
Amlodipine-perindopril + Gold sodium thiomalate
Severity: Moderate
Amlodipine-perindopril and Gold sodium thiomalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors given with injectable gold have been linked to nitritoid reactions, with facial flushing, nausea, vomiting and hypotension. These reactions are uncommon but can be distressing and may cause significant blood pressure drops.
What this interaction means in plain words
Amlodipine-perindopril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; possible vasomotor effects potentiated by ACE inhibition.
What to do
Monitor patients for flushing and hypotension after each gold injection, particularly early in therapy. Consider an alternative to the ACE inhibitor or to gold if reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Gold sodium thiomalate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Gold sodium thiomalate?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors given with injectable gold have been linked to nitritoid reactions, with facial flushing, nausea, vomiting and hypotension. These reactions are uncommon but can be distressing and may cause significant blood pressure drops.
How serious is the interaction between Amlodipine-perindopril and Gold sodium thiomalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for flushing and hypotension after each gold injection, particularly early in therapy. Consider an alternative to the ACE inhibitor or to gold if reactions recur.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
