Drug interactions
Amlodipine-perindopril + Grapefruit
Severity: Minor
Amlodipine-perindopril and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and can slightly raise amlodipine concentrations. The effect on amlodipine is small and rarely clinically relevant, unlike with other dihydropyridines.
What this interaction means in plain words
Amlodipine-perindopril and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Furanocoumarins in grapefruit inhibit intestinal CYP3A4, reducing first-pass metabolism of amlodipine.
What to do
No restriction is usually needed; advise patients to report dizziness, flushing or ankle swelling if they consume large amounts of grapefruit.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Grapefruit?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and can slightly raise amlodipine concentrations. The effect on amlodipine is small and rarely clinically relevant, unlike with other dihydropyridines.
How serious is the interaction between Amlodipine-perindopril and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No restriction is usually needed; advise patients to report dizziness, flushing or ankle swelling if they consume large amounts of grapefruit.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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