Drug interactions
Amlodipine-perindopril + Heparin
Severity: Moderate
Amlodipine-perindopril and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone production in the adrenal gland, and ACE inhibitors such as perindopril also reduce aldosterone. Together they can raise serum potassium, particularly in patients with renal impairment, diabetes or other risk factors for hyperkalemia.
What this interaction means in plain words
Amlodipine-perindopril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone secretion by heparin and ACE inhibition leads to potassium retention.
What to do
Monitor serum potassium and renal function when heparin is given with perindopril, especially if therapy exceeds several days. Treat hyperkalemia if it develops and reassess the need for either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Amlodipine-perindopril with Heparin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone production in the adrenal gland, and ACE inhibitors such as perindopril also reduce aldosterone. Together they can raise serum potassium, particularly in patients with renal impairment, diabetes or other risk factors for hyperkalemia.
How serious is the interaction between Amlodipine-perindopril and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when heparin is given with perindopril, especially if therapy exceeds several days. Treat hyperkalemia if it develops and reassess the need for either drug.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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