Drug interactions
Amlodipine-perindopril + Hydrocortisone
Severity: Minor
Amlodipine-perindopril and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer and could slightly reduce amlodipine exposure. Its mineralocorticoid action may also cause sodium and fluid retention that counters antihypertensive therapy.
What this interaction means in plain words
Amlodipine-perindopril and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Weak CYP3A4 induction and sodium retention from hydrocortisone.
What to do
Monitor blood pressure and fluid status during sustained hydrocortisone therapy and adjust antihypertensives if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Amlodipine-perindopril with Hydrocortisone?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer and could slightly reduce amlodipine exposure. Its mineralocorticoid action may also cause sodium and fluid retention that counters antihypertensive therapy.
How serious is the interaction between Amlodipine-perindopril and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and fluid status during sustained hydrocortisone therapy and adjust antihypertensives if needed.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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