Drug interactions
Amlodipine-perindopril + Insulin degludec / insulin aspart
Severity: Moderate
Amlodipine-perindopril and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity, which may enhance the glucose-lowering effect of insulin. Hypoglycemia can occur, particularly in the first weeks of combined therapy.
What this interaction means in plain words
Amlodipine-perindopril and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Improved insulin sensitivity with ACE inhibition adds to insulin's glucose-lowering effect.
What to do
Monitor blood glucose more frequently when perindopril is started or the dose changed. Reduce insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity, which may enhance the glucose-lowering effect of insulin. Hypoglycemia can occur, particularly in the first weeks of combined therapy.
How serious is the interaction between Amlodipine-perindopril and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when perindopril is started or the dose changed. Reduce insulin dose if hypoglycemia occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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